BioSpyder Launches TempO-PAINT™ for Integrated Cell Painting and Gene Expression Profiling

CARLSBAD, CA — November 3rd, 2026 — BioSpyder Technologies announces the launch of TempO-Paint™, a high-throughput assay combining cell painting and transcriptomic profiling from the same biological wells. The platform integrates cellular morphology and gene expression data, enabling researchers to study phenotypic changes alongside their underlying molecular responses. 

Traditional cell painting and transcriptomics workflows often require separate sample preparations. TempO-PAINT addresses this limitation by using BioSpyder's extraction-free TempO-Seq® technology to measure gene expression directly from cells following high-content imaging, reducing sample requirements and simplifying experimental design. 

Key Features of TempO-Paint 

  • Same-Well Analysis: Combines cell painting imaging and RNA expression profiling without requiring separate replicate plates. 

  • High-Throughput Screening: Compatible with 96- and 384-well formats for large-scale compound screening. 

  • Flexible Transcriptomics: Supports targeted gene panels and whole-transcriptome profiling. 

  • Integrated Biological Data: Connects changes in cellular morphology with gene expression to investigate mechanisms of action and treatment responses. 

Applications in Drug Discovery and Toxicology 

TempO-PAINT supports high-throughput screening, drug discovery, toxicology, and mechanistic studies. By capturing morphological and transcriptomic data from the same wells, researchers can characterize compound responses, investigate biological pathways, and prioritize candidates for further investigation. 

About BioSpyder Technologies 

BioSpyder Technologies develops high-throughput molecular profiling technologies for drug discovery, toxicology, and biomedical research. Its portfolio includes TempO-Seq®, TempO-LINC™, TempO-Seq DBS, TempO-Seq miRNA and TempO-PAINT™, supporting scalable gene expression analysis across diverse research applications. 

Learn more about TempO-Paint: https://www.biospyder.com/tempo-paint 

Contact: info@biospyder.com 

Ayokunmi Akanle